Biker acid can help without cocaine use

Bile acids that help with fat digestion can also reduce the “rewarding” feelings of cocaine use, according to a study published recently in  PLOS Biology by India Reddy, Nicholas Smith, and Robb Flynn of Vanderbilt University, Aurelio Galli of the University of Alabama at Birmingham, and their colleagues, according to Science Daily. The results show promise for potential new strategies for treatment of cocaine abuse.

This study builds on evidence that bile acids influence the brain’s reward system. Bile acids are normally released from the gall bladder into the upper part of the small intestine, where they break down fats for absorption, before being recycled further down the small intestine. In bile diversion surgery, which is an experimental treatment for weight loss, bile is released at the end of the small intestine, increasing the amount of bile acids that enter the general circulation.

The researchers first showed that the surgery produced an increase of bile acids in the brain, resulting in a reduction in dopamine release in response to cocaine. Mice receiving the surgery also showed less preference for the cocaine-associated chamber, indicating that cocaine was probably less rewarding.

The researchers then administered a drug, called OCA, that mimics the effect of bile at its receptor in the brain, called TGR5. They found that OCA mimicked cocaine-related results of surgery in untreated mice. Removing TGR5 from the brain’s nucleus accumbens, a central reward region, prevented bile acids from reducing cocaine’s effects, confirming the hypothesis.

“These findings redefine the physiological significance of bile acid signaling and highlight the importance of determining whether bile acid analogues represent a viable pharmacological treatment for cocaine abuse,” Galli said.



Alex Trebek likely to leave ‘Jeopardy’ in 2020

Celebrated Jeopardy! host Alex Trebek has hinted that he will likely be leaving the game show in 2020.

Trebek, who has hosted the show since 1984, said that the chances of him returning after his contract expires in 2020 are “50-50 and a little less” during an interview with Harvey Levin that aired Sunday on Fox News.

“I mentioned to our producer not so long ago that the fellow that does play-by-play for the Los Angeles Kings — they should consider him,” Trebek said. That fellow, 28-year-old Alex Faust, became the play-by-play announcer on FOX Sports West in 2017.

Laura Coates, an attorney who regularly appears on CNN as a legal analyst, was another suggestion. Coates tweeted later on that she would be interested in the job and said that Jeopardy! was her favorite game show as a child.

“Still watch w/my own kids (who saw him say this & now think I’m a genius) #Dying,” she wrote in her tweet.

Trebek is the longest-running host of Jeopardy! and last renewed his contract in 2017. He seemed confident in his interview that he would not miss the show too much after retiring.

Trebek is also deeply involved in the production of the game show, though it is unclear whether he will remain on the show in a production capacity after retiring as host.

HOUNDS_Entertainment Music

Neil Diamond thanks Colorado firefighters with performance

Singer Neil Diamond surprised firefighters with a performance in appreciation for their battling a blaze near his Colorado home.

According to Rolling Stone, the 77-year-old Rock and Roll Hall of Famer took to the stage Friday night to play “Sweet Caroline” for dozens of firefighters gathered at the command post for a fire burning near Basalt in central Colorado.

Diamond retired abruptly from touring in January after he says he was diagnosed with Parkinson’s disease.

Two people are accused of igniting the Lake Christine Fire on July 3 by firing incendiary tracer rounds at a shooting range.

The 20-square mile (51-square kilometer) fire has destroyed three homes. About 450 people are helping battle the blaze, which is mostly contained.

Diamond and his wife, Katie McNeil, visited the incident command post at the fire near Basalt to meet and thank firefighters, KDVR reported.

He sat down in front of the large group with a guitar and the firefighters were treated to a sing-along of “Sweet Caroline.”

About 450 firefighters have been battling the Lake Christine Fire, which has burned about 12,000acress and was 45 percent contained as of Saturday morning.  It started July 3 at a shooting range; two people face arson charges.

“I want to take you all home, I want to give you a kiss, I want to make dinner for you, and I just want to say thank you from the people of this area for coming down and this town has not been this happy since… I don’t know,” Diamond told the hundreds of firefighters.


Meghan Markle’s dad slams her for ignoring him

Thomas Markle, Meghan Markle’s father, has blasted the Duchess of Sussex for ignoring him, claiming he made Meghan the woman she is today and fears he won’t be able to meet his future grandchildren in his latest tirade against his daughter and the royal family.

Speaking with The Mail on Sunday at his home in Mexico, Markle said his daughter had cut off all communication with him after he spoke out against the royal family.

“I’m really hurt that she’s cut me off completely. I used to have a phone number and text number for her personal aides at the Palace, but after I said a few critical words about the royal family changing Meghan, they cut me off,” Markle told the site.

According to Fox News, Markle previously said the royal family stopped speaking to him after the staged paparazzi photo scandal just days before Meghan and Harry’s wedding in May. On Sunday, Markle admitted the pictures were a “huge” mistake-but accused his daughter of being cruel despite everything he did for her while she was growing up.

“I tell you, I’ve just about reached my limit with Meghan and the royal family. They want me to be silent, they want me to just go away. But I won’t be silenced,” Markle said. “I refuse to stay quiet. What riles me is Meghan’s sense of superiority. She’d be nothing without me. I made her the Duchess she is today. Everything that Meghan is, I made her.”

The 74-year-old recalled raising Meghan with his ex-wife Doria Ragland until she was 6. Meghan moved back in with her father from age 11 to 17, according to Markle.

HOUNDS_Entertainment Music

Justin Bieber: Getting married is my next agenda

Hot on the heels of Justin Bieber’s new summer song, “No Brainer”-with DJ Khaled, Quavo, and Chance the Rapper-the singer has something else up his sleeve. And it has nothing to do with music.

When paparazzi spotted Bieber in NYC with his fiancée and asked what is next on his to-do list, the pop star candidly answered: “Getting married.”

“Who’s the lucky girl?” asked the man behind the camera.

Bieber smiled and pointed to his fiancée, model Hailey Baldwin, before touching her hand and continuing on his way.

According to TMZ, this seems to be the first time Bieber acknowledges Hailey as his bride-to-be on camera. She was a bit more bashful than he was being put on the spot, but sure seemed to appreciate the sweet shout-out.

TMZ broke the story when Justin proposed to Hailey earlier this month in the Bahamas. She obviously said yes, and was more than happy to flaunt the huge engagement ring he bought for her which set him back $500,000 give or take.

They’ve been inseparable since getting engaged, and it seems even the prospect of conquering the charts isn’t that a big deal to Biebs with marriage on his mind.

First of all, they are too cute together. Second of all, this seems to imply that the wedding is right around the corner. And it looks like planning is well under way-in fact, Justin and Hailey were spotted meeting with a pastor on July 29, and Hailey even had a notebook with her.


Homicides using guns are up

Homicides using guns are up according to NBC News. The number of gun homicides has gone up by nearly a third nationwide in recent years, according to new data from the Centers for Disease Control and Prevention.

The CDC found a 31 percent increase in homicides involving firearms from 2014 to 2016, which is shocking. In 2014, 11,008 homicides involved a gun. That number rose to 14,415 by 2016, the CDC team said.

The CDC actually regularly reports this type of statistics. Their latest report is based on death certificates. The CDC also regularly reports on gun deaths, however its role in researching the underlying causes has actually been limited by the so-called Dickey Amendment, which is added on to congressional funding legislation every year. It kerps the CDC from using federal funding to “advocate or promote gun control.”

The shocking information is that the U.S. leads the world in gun related deaths, but there’s disagreement over how much of a role is played by the high rates of firearm ownership in the U.S. and the relative lack of regulation on who can buy guns and what kind of weapons are made readily available. One study in 2015 found that as many as one in three Americans owned a gun.

Daniel Webster, a gun policy expert at the Johns Hopkins Bloomberg School of Public Health, said that one surprising factor behind the recent increase in gun killings is the outcry against police killings of unarmed people.

Gun deaths went up in Baltimore, he said, and so the police has been pulled back from much of the patrolling. It‘s obvious that something has to be done about gun violence.

HOUNDS_Entertainment SPORT

Ex-WWE wrestler Brian Christopher dead at age 46

Former World Wrestling Entertainment wrestler Brian Christopher-real name Brian Lawler-, died Sunday after reportedly hanging himself in a Memphis, Tennessee, jail, according to Dave Meltzer of the Wrestling Observer.

Christopher, the son of WWE Hall of Famer Jerry “The King” Lawler, was 46 years old. According to Yahoo Sports, Christopher was placed on life support and surrounded by his family at the time of his death.

“Corrections officers administered CPR until paramedics arrived,” the Tennessee Bureau of Investigation said in a statement. “Lawler was transported to Regional One Medical Center in Memphis where he died Sunday afternoon.”

“WWE is saddened to learn that Brian Christopher Lawler, who is best known in WWE as Too Cool’s Grandmaster Sexay, has passed away,” the WWE said in a statement. “Lawler, who is the son of WWE Hall of Famer Jerry “The King” Lawler, competed during the height of the Attitude Era. WWE extends its condolences to Lawler’s family, friends and fans.”

Christopher was arrested on July 7 for DUI and evading Tennessee police officers. Police said Brian Christopher exhibited erratic behavior and initially refused to stop his car when officers tried to pull him over early on July 7.

When police searched his car, a 12-ounce can of alcohol was reportedly found open in his car’s center console and his bail was set at $40,000. In June, Christopher was arrested for allegedly not having the funds to cover a hotel bill at the Hampton Inn in Memphis, Tennessee, according to TMZ Sports.

TMZ previously reported that Brian Christopher tried to hang himself in his jail cell outside Memphis.


Demi Lovato still hospitalized due to overdose complications

Demi Lovato is still in the hospital due to complications resulting from a drug overdose she experienced last week, according to TMZ.

Sources say that the pop singer is suffering from extreme nausea and a high fever, among other symptoms.

Lovato was unconscious when paramedics arrived to help her, and she was revived with Narcan, which is commonly used to reverse opioid overdoses. Neither Lovato nor her friends who were present at the time of the overdose told the paramedics which drugs Lovato was using when she overdosed.

According to a source, doctors have said that Lovato is expected to make a full recovery, though a date for her release from the hospital has not yet been set.

It’s unclear whether Lovato will go to a rehab facility after she is released from hospitalization, though family and friends have reportedly been suggesting the idea to her in the months after she broke her six-year sobriety. Lovato recently released a song, “Sober,” in which she apologized for the lapse

TMZ also reported that Lovato’s manager, Phil McIntyre, left her team after he unsuccessfully tried to stage an intervention with other members of Lovato’s team.

The singer overdosed on drugs last Tuesday, when she was out celebrating a backup dancer’s birthday. The person who made the 911 call requested that paramedics arrive at Lovato’s without sirens and lights so as not to draw attention to the situation, though the dispatcher said that would not be possible.




Cooking oil is helpful against bacteria

Cooking oil coating can prevent bacteria growth, according to Science Daily. It’s interesting to know that foods produced on an industrial scale also include raw ingredients that are mixed together in enormous stainless steel machines that can be difficult to clean. With repeated use, equipment surfaces can get minute scratches and grooves, providing bacteria and biofilms the perfect place to grow.

It‘s interesting to note that  surface scratches may appear small to the naked eye, they are however significantly bigger to bacteria, which are only a few micrometers in size. Surface-trapped food residue and bacteria then increase the risk of contamination that is possible from microorganisms such as Salmanella and E.Coli.

Professor Ben Hatton of the University of Toronto’s Department of Materials Science & Engineering, Dr. Dalal Asker and Dr. Tarek Awad are researching cheaper, safer and more effective ways to prevent bacteria from growing inside these machines. This minimizes the risk of cross contamination, which can lead to disease. Their team has also proposed using a thin layer of cooking oil at the metal surface to fill in microscopic scrapes, cracks and fissures and create a barrier to bacterial attachment.

“Coating a stainless steel surface with an everyday cooking oil has proven remarkably effective in repelling bacteria,” says Hatton who collaborated on the project with AGRI-NEO, an Ontario company looking for a solution to a common problem in its industry. “The oil fills in the cracks, creates a hydrophobic layer and acts as a barrier to contaminants on the surface.”


Bow Wow promises to quit music, give away money

Rapper and actor Bow Wow said in a series of tweets on Monday that he would be giving away all of his money and quitting music, Rap-Up reported.

Bow Wow responded to a fan’s tweet accusing him of cheating on his girlfriend, Kiyomi Leslie, then continued on a tirade telling fans to leave him and Leslie alone.

“I say this with LOVE,” he said in his expletive-filled series of tweets. “You can clown all day about me but once u put my girl in it I’m trippn [sic]! F-k this famous s-t.”

In a now-deleted tweet, he said that he would quit the music industry.

“Down size my home,” he suggested. “Sale everything. And go work at gamestop. I’d probably be the happiest man in the world.”

Bow Wow also began giving money away via the Cash app, sending at least one fan $500.

“If you want some free money y’all can have it … Let’s see if money makes you happy,” he tweeted.

Bow Wow was scheduled to join the So So Def 25th Anniversary tour, but recently said that because he feels he is always in the news he would be better off not going so as not to disturb the other performers and organizers of the tour.

Before finally logging off of Twitter, the rapper said that he had plenty of time to deal with the people with whom he was angry, but that he would have to go see his therapist later to help calm down.